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The functional activity of epithelial melanocytes is regulated by biological agents in the microenvironment, including proopiomelanocortin-derived peptides, and by reciprocal interactions between melanocytes on the one hand and neighbouring keratinocytes and signals from the underlying lamina propria on the other hand

doi: 10.1056/NEJM196102022640505 99 McCONAHEYWMWoolnerLBBlackBMKeatingFR

They only mimic what GLP-1 doestemporarilyand come with a long list of side effects like nausea, bloating, digestive issues, and even muscle loss